Pseudocoptisine chloride (Synonyms: 盐酸异黄连碱; Isocoptisine chloride)

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Pseudocoptisine chloride  (Synonyms: 盐酸异黄连碱; Isocoptisine chloride) 纯度: 99.36%

Pseudocoptisine (Isocoptisine) chloride 是一种具有苄基异喹啉骨架的季生物碱。Pseudocoptisine chloride 可抑制乙酰胆碱酯酶 (AChE) 活性，IC50 为 12.8 μM。具有抗发炎和健忘作用。

Pseudocoptisine chloride (Synonyms: 盐酸异黄连碱; Isocoptisine chloride)

Pseudocoptisine chloride Chemical Structure

CAS No. : 30044-78-1

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Pseudocoptisine chloride 相关产品

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生物活性

Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2].

体外研究
(In Vitro)

Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells[2].
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions[1].
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Pseudocoptisine chloride 相关抗体:
体内研究
(In Vivo)

The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

355.77

Formula

C19H14ClNO4
CAS 号

30044-78-1
性状

固体

颜色

Yellow to brown

中文名称

盐酸异黄连碱
结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
  • Alkaloids
  • Piperidine Alkaloids
初始来源
  • 植物
  • 罂粟科
  • 齿瓣延胡索
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 1 mg/mL (2.81 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8108 mL 14.0540 mL 28.1080 mL
5 mM — — —
10 mM — — —

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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浓度

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体积

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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

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浓度 (final)

C2

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体积 (final)

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动物溶解方案

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给药剂量

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动物的平均体重

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计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.36%

Data Sheet (600 KB) SDS (252 KB)

COA (172 KB) LCMS (94 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Hung TM, et al. Anti-amnestic activity of pseudocoptisine from Corydalis Tuber. Biol Pharm Bull. 2008;31(1):159-162.  [Content Brief]

    [2]. Yun KJ, et al. Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE(2), and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage c  [Content Brief]

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