MAHMA NONOate

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MAHMA NONOate 

MAHMA NONOate 是 NO 供体。MAHMA NONOate 有效抑制胶原蛋白或 ADP 诱导的血小板聚集。

MAHMA NONOate

MAHMA NONOate Chemical Structure

CAS No. : 146724-86-9

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5 mg ￥600 In-stock
10 mg ￥1000 In-stock
25 mg ￥2050 In-stock
50 mg ￥3300 In-stock
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MAHMA NONOate 相关产品

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生物活性

MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP[1].

体外研究
(In Vitro)

MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP[1].
MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

MAHMA NONOate 相关抗体:
体内研究
(In Vivo)

MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats anaesthetised with pentobarbitone[2]
Dosage: 0.3-10 nmol/kg/min
Administration: Intravenous injection; 0.3-10 nmol/kg/min once
Result: Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.

分子量

204.27

Formula

C8H20N4O2
CAS 号

146724-86-9
性状

固体

颜色

Off-white to light yellow

结构分类
  • Alkaloids
  • Other Alkaloids
初始来源
  • 内源性代谢物
运输条件

Shipping with dry ice.
储存方式

-80°C

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
In Vitro: 

H2O 中的溶解度 : 62.5 mg/mL (305.97 mM; adjust pH to 10 with NaOH)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.8955 mL 24.4774 mL 48.9548 mL
5 mM 0.9791 mL 4.8955 mL 9.7910 mL
10 mM 0.4895 mL 2.4477 mL 4.8955 mL

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* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

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浓度 (final)

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体积 (final)

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动物溶解方案

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给药剂量

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工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
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纯度 & 产品资料

Data Sheet (587 KB) SDS (251 KB)

COA (187 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Homer KL, Wanstall JC. Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate. Br J Pharmacol. 2002 Dec;137(7):1071-81.  [Content Brief]

    [2]. Homer KL, Wanstall JC. Platelet inhibitory effects of the nitric oxide donor drug MAHMA NONOate in vivo in rats. Eur J Pharmacol. 2003 Dec 15;482(1-3):265-70.  [Content Brief]

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