Virodhamine

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Virodhamine  纯度: ≥98.0%

Virodhamine 是一种内源性大麻素，它通过激活大麻素 (CB) 受体调节神经传递。Virodhamine 是 CB1 受体的拮抗剂和 CB2 受体的激动剂。Virodhamine 通过触发 MAPK 信号和 ROS 的产生诱导巨核细胞分化。 Virodhamine 可用于治疗各种神经疾病，如阿尔茨海默病和帕金森。

Virodhamine

Virodhamine Chemical Structure

CAS No. : 287937-12-6

规格 价格 是否有货 数量
5 mg ￥850 In-stock
10 mg ￥1450 In-stock
25 mg ￥3000 In-stock
50 mg ￥4850 In-stock
100 mg ￥7800 In-stock
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Virodhamine 相关产品

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生物活性

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer’s and Parkinson’s diseases[1][2].

体外研究
(In Vitro)

Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus[1].
Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1[1].
Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control[1].
Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Virodhamine 相关抗体:

RT-PCR[1]

Cell Line: Megakaryocyte cell line
Concentration: 10, 20 and 40 μM
Incubation Time: 72 h
Result: Dose‐dependently enhanced the expression level of megakaryocytic marker CD61 and the expression of TRPV1 mRNA.

体内研究
(In Vivo)

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety[2]
Dosage: 1, 5 and 10 mg/kg
Administration: Intraperitoneal injection; 1-10 mg/kg; once
Result: Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.

分子量

347.53

Formula

C22H37NO2
CAS 号

287937-12-6
性状

粘稠液体

颜色

Yellow to brown

结构分类
  • Alkaloids
  • Other Alkaloids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 100 mg/mL (287.74 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8774 mL 14.3872 mL 28.7745 mL
5 mM 0.5755 mL 2.8774 mL 5.7549 mL
10 mM 0.2877 mL 1.4387 mL 2.8774 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (598 KB) SDS (251 KB)

COA (159 KB) HNMR (249 KB) MS (176 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Sharma DS, et al. Virodhamine, an endocannabinoid, induces megakaryocyte differentiation by regulating MAPK activity and function of mitochondria. J Cell Physiol. 2021 Feb;236(2):1445-1453.  [Content Brief]

    [2]. Hayase T. Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors. BMC Neurosci. 2013 Feb 9;14:20.  [Content Brief]

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