c-di-AMP diammonium (Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
c-di-AMP diammonium  (Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium) 纯度: 99.36%

c-di-AMP diammonium 是 STING 激动剂，其与 STING 结合，从而激活 TBK3-IRF3 信号传导途径，随后引发 I 型 IFN 和 TNF 产生。c-di-AMP diammonium 是一种细菌第二信使，主要在革兰氏阳性细菌中，可调节细胞生长，存活以及毒力。c-di-AMP diammonium 也调节宿主免疫反应。c-di-AMP diammonium 可作为一种有效的粘膜佐剂，刺激体液和细胞反应。

c-di-AMP diammonium (Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium)

c-di-AMP diammonium Chemical Structure

规格 价格 是否有货 数量
500 μg ￥1300 In-stock
1 mg ￥1800 In-stock
5 mg ￥4800 In-stock
10 mg ￥7500 In-stock
50 mg   询价  
100 mg   询价  

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c-di-AMP diammonium 相关产品

•相关化合物库:

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  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library

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生物活性

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].

IC50 & Target

STING[3]
体外研究
(In Vitro)

c-di-AMP diammonium signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].
c-di-AMP diammonium combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

c-di-AMP diammonium 相关抗体:
分子量

692.47

Formula

C20H30N12O12P2
性状

固体

颜色

White to off-white

中文名称

环二腺苷酸(联胺)
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

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给药剂量

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动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.36%

Data Sheet (599 KB) SDS (251 KB)

COA (174 KB) RP-HPLC (203 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8).  [Content Brief]

    [2]. Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519.  [Content Brief]

    [3]. Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31.  [Content Brief]

    [4]. Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824.  [Content Brief]

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