Netropsin dihydrochloride (Synonyms: 纺锤菌素二盐酸； 纺锤菌素)

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Netropsin dihydrochloride  (Synonyms: 纺锤菌素二盐酸； 纺锤菌素) 纯度: 99.35%

Netropsin dihydrochloride 是一种小分子(MGB) 小沟结合剂，抑制分离的拓扑异构酶的催化活性，并干扰拓扑异构酶 II 和 I 在细胞核中的可降解复合物的稳定性。Netropsin dihydrochloride 对牛痘病毒具有抗病毒活性。

Netropsin dihydrochloride (Synonyms: 纺锤菌素二盐酸； 纺锤菌素)

Netropsin dihydrochloride Chemical Structure

CAS No. : 18133-22-7

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1 mg ￥2880 In-stock
5 mg ￥7200 In-stock
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Netropsin dihydrochloride 相关产品

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生物活性

Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei[1]. Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus[4].

体外研究
(In Vitro)

Netropsin dihydrochloride has potential antibiotic and antiviral properties by binding to dsDNA in a non-intercalative manner, it improves survival from murine endotoxaemia by attenuating NOS2 induction through interference with HMGA1 DNA binding to the core NOS2 promoter[2].
Netropsin dihydrochloride in solutions of DNA has radioprotective ability against radiation-induced damage due to its high binding affinity and high structural stabilization, hydroxyl radical (OH*) generated by ionizing radiation cannot radiolyse the netropsin-DNA complex[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Netropsin dihydrochloride 相关抗体:
分子量

503.39

Formula

C18H28Cl2N10O3
CAS 号

18133-22-7
性状

固体

颜色

Off-white to yellow

中文名称

纺锤菌素二盐酸； 纺锤菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (248.32 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 20 mg/mL (39.73 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9865 mL 9.9327 mL 19.8653 mL
5 mM 0.3973 mL 1.9865 mL 3.9731 mL
10 mM 0.1987 mL 0.9933 mL 1.9865 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

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体积 (start)

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浓度 (final)

C2

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体积 (final)

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纯度 & 产品资料

纯度: 99.35%

Data Sheet (598 KB) SDS (252 KB)

COA (260 KB) HNMR (281 KB) LCMS (265 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090(1):52-60.  [Content Brief]

    [2]. Grant MA, et al. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15;418(1):103-12.  [Content Brief]

    [3]. Mishra K et al. Netropsin, a minor groove binding ligand: a potential radioprotective agent. Radiat Res. 2009 Dec;172(6):698-705.  [Content Brief]

    [4]. Smee DF, et, al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.  [Content Brief]

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