Moringin (Synonyms: 辣木籽素)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Moringin  (Synonyms: 辣木籽素) 纯度: 99.95%

Moringin 是一种有效的选择性 TRPA1 离子通道天然激动剂，EC50 为 3.14 μM。Moringin 不会激活或非常微弱地激活香草素体感通道 TRPV1、TRPV2、TRPV3 和 TRPV4，以及褪黑素冷却受体 TRPM8。Moringin 具有降血糖、抗菌、抗炎、抗癌和神经保护活性。

Moringin (Synonyms: 辣木籽素)

Moringin Chemical Structure

CAS No. : 73255-40-0

规格 价格 是否有货 数量
1 mg ￥1863 In-stock
5 mg ￥4100 In-stock
10 mg ￥6500 In-stock
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Moringin 相关产品

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生物活性

Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities[1][2].

体外研究
(In Vitro)

在 SH-SY5Y 人神经母细胞瘤细胞中，Moringin（16.4 µM；24-72 小时）以时间和浓度依赖性方式显着降低 SH-SY5Y 细胞生长[2]。
Moringin (1.64-8.2 μM; 24 h) 在 SH-SY5Y 细胞中增加 p53、p21 和 Bax 在蛋白质和转录水平的表达。 Moringin 显著增加 caspase 3/9 的基因表达并增强它们的切割，从而启动内在的细胞凋亡级联反应[2]。
Moringin 抑制 NF-κB 的核转位[2]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Moringin 相关抗体:
体内研究
(In Vivo)

在实验性自身免疫性脑脊髓炎 (EAE) 小鼠中，Moringin (10 mg/kg；腹腔注射；每天 1 次，共 5 周) 预处理可使异常的 Wnt-β-catenin 通路正常化，导致 GSK3β 抑制和 β-catenin 上调，从而调节 T 细胞活化 ( CD4 和 FoxP3)，通过激活 PPARγ 抑制主要的炎症介质 (IL-1β、IL-6 和 COX2)。 辣木苷增加 EAE 小鼠体内抗氧化 Nrf2 的表达[3]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

311.35

Formula

C14H17NO5S
CAS 号

73255-40-0
性状

固体

颜色

White to light yellow

中文名称

辣木籽素
结构分类
  • Others
初始来源
  • 植物
  • 辣木科
  • 辣木
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.95%

Data Sheet (533 KB) SDS (479 KB)

COA (190 KB) RP-HPLC (172 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Gigliola Borgonovo, et al. Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. Molecules. 2020 Feb 22;25(4):976.  [Content Brief]

    [2]. Santa Cirmi, et al. Moringin from Moringa Oleifera Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors. Int J Mol Sci. 2019 Apr 19;20(8):1930.  [Content Brief]

    [3]. Sabrina Giacoppo, et al. Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis. Drug Des Devel Ther. 2016 Oct 4;10:3291-3304.  [Content Brief]

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