Hispolon

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Hispolon  纯度: 99.67%

Hispolon 是一种多酚，可从桑黄 (Phellinus linteus) 中分离得到。Hispolon 具有抗癌、抗糖尿病、抗氧化、抗病毒、肝保护活性、抗糖尿病和抗炎活性。

Hispolon

Hispolon Chemical Structure

CAS No. : 173933-40-9

规格 价格 是否有货 数量
1 mg ￥760 In-stock
5 mg ￥1900 In-stock
10 mg ￥3000 In-stock
25 mg ￥6000 In-stock
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100 mg   询价  

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Hispolon 相关产品

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生物活性

Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities[1].

体外研究
(In Vitro)

Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells[2].
Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells[2].
Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21[2].
Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Hispolon 相关抗体:

Cell Viability Assay[2]

Cell Line: U87MG cells
Concentration: 25 and 50 μM
Incubation Time: 24, 48, 72 h
Result: Inhibited cell viability in a dose and time dependent way.

Western Blot Analysis[2]

Cell Line: U87MG cells
Concentration: 25 and 50 μM
Incubation Time: 2, 4, 8 h
Result: Decreased cyclin D4 level, and increased p21 level.

体内研究
(In Vivo)

Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice[3].
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced acute lung injury mice[3]
Dosage: 2.5, 5 and 10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Alleviated the pathological effects in the LPS-challenged mouse.
Reduced the W/D ratio in the lung and MPO activity.
Decreased pro-Inflammatory cytokine production.
Animal Model: DBTRG xenograft mice[4]
Dosage: 5 and 10 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Reduced tumor volume (RTV).
Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.

分子量

220.22

Formula

C12H12O4
CAS 号

173933-40-9
性状

固体

颜色

Light yellow to yellow

结构分类
  • Phenols
  • Polyphenols
初始来源
  • 微生物

Phellinus linteus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (567.61 mM; 超声助溶 (<70°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.5409 mL 22.7046 mL 45.4091 mL
5 mM 0.9082 mL 4.5409 mL 9.0818 mL
10 mM 0.4541 mL 2.2705 mL 4.5409 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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浓度

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体积

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

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体积 (start)

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浓度 (final)

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体积 (final)

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动物溶解方案

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给药剂量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.67%

Data Sheet (603 KB) SDS (251 KB)

COA (167 KB) HNMR (242 KB) LCMS (265 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Sarfraz A, et al. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020 Nov;190:110017.

    [2]. Arcella A, et al. Effects of hispolon on glioblastoma cell growth. Environ Toxicol. 2017 Sep;32(9):2113-2123.  [Content Brief]

    [3]. Huang CY, et al. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020 Jun 10;12(6):1742.  [Content Brief]

    [4]. Liao KF, et al. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021 Jul 26;26(15):4497.  [Content Brief]

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