K-252c

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K-252c  纯度: ≥99.0%

K-252c，一种十字孢碱的类似物，可从Nocardiopsis sp.中分离得到，是一种能透过细胞的、PKC 的抑制剂，IC50 值为2.45 µM。K-252c可诱导人慢性粒细胞白血病癌细胞凋亡。K-252c还能抑制β内酰胺酶、胰凝乳蛋白酶和苹果酸脱氢酶。

K-252c

K-252c Chemical Structure

CAS No. : 85753-43-1

规格 价格 是否有货 数量
1 mg ￥3800 In-stock
5 mg ￥8900 询价
10 mg   询价  
50 mg   询价  

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K-252c 相关产品

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生物活性

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].

IC50 & Target

IC50: 2.45 µM (PKC)[1].
分子量

311.34

Formula

C20H13N3O
CAS 号

85753-43-1
性状

固体

颜色

White to off-white

结构分类
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 微生物

Nocardiopsis sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (539 KB) SDS (251 KB)

COA (272 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Pereira, E.R., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties J. Med. Chem. 39(22), 4471-4477 (1996).  [Content Brief]

    [2]. Liu, R., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2 Arch. Pharm. Res. 30(3), 270-274 (2007).  [Content Brief]

    [3]. Zimmermann, A., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48(1), 49-60 (2000).  [Content Brief]

    [4]. McGovern, S.L., et al. Kinase inhibitors: Not just for kinases anymore Journal of Medicinal Chemistry 46, 1478-1483 (2003).  [Content Brief]

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