Nicotinamide riboside tartrate (Synonyms: 烟酰胺核糖酒石酸盐)

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Nicotinamide riboside tartrate  (Synonyms: 烟酰胺核糖酒石酸盐)

Nicotinamide riboside tartrate 是具有口服活性的 NAD+ 的前体，增加 NAD+ 水平并激活 SIRT1 和 SIRT3。Nicotinamide riboside tartrate 是维生素 B3 (烟酸) 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。Nicotinamide riboside tartrate 可以减少阿尔茨海默氏病转基因小鼠模型中的认知退化。

Nicotinamide riboside tartrate (Synonyms: 烟酰胺核糖酒石酸盐)

Nicotinamide riboside tartrate Chemical Structure

CAS No. : 2415657-86-0

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Nicotinamide riboside tartrate 的其他形式现货产品:

Nicotinamide riboside chloride

Nicotinamide riboside tartrate 相关产品

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生物活性

Nicotinamide riboside tartrate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50 & Target[1]

SIRT1

 

SIRT3

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Nicotinamide riboside tartrate (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside tartrate increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].
Nicotinamide riboside tartrate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Nicotinamide riboside tartrate 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.5 mM
Incubation Time: 24 hours
Result: Reduced the acetylation status of Ndufa9 and SOD2.

体内研究
(In Vivo)

Chronic Nicotinamide riboside tartrate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-week-old C57Bl/6J mice[1]
Dosage: 400 mg/kg
Administration: PO; daily; for 16 weeks
Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.

Clinical Trial

分子量

404.33

Formula

C15H20N2O11
CAS 号

2415657-86-0
中文名称

烟酰胺核糖酒石酸盐
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (544 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.  [Content Brief]

    [2]. Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer’s Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8.  [Content Brief]

    [3]. Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.  [Content Brief]

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