(-)-Cleistenolide (Synonyms: Cleistenolide)

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(-)-Cleistenolide (Synonyms: Cleistenolide)

(-)-Cleistenolide 是一种 α,β- 不饱和 δ- 内酯，从Cleistochlamys kirkii Oliver 中分离得到。(-)-Cleistenolide 具有抗菌和抗肿瘤活性。

(-)-Cleistenolide Chemical Structure

CAS No. : 1003600-48-3

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(-)-Cleistenolide 相关产品

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生物活性

(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity^[1].

体外研究
(In Vitro)

(-)-Cleistenolide (compound 1) exhibits potent cytotoxicity against cancer cell lines and low cytotoxicity in normal cells MRC-5^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Cleistenolide 相关抗体:

Cell Cytotoxicity Assay

Cell Line:	K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549 and MRC-5^[1]
Concentration:	0-100 μM
Incubation Time:
Result:	Exhibited potent cytotoxicity against cancer cell lines with IC₅₀s of 7.65 μM, 1.21 μM, 14.22 μM, 36.94 μM, 26.07 μM, 2.25 μM, 7.32 μM and 16.34 μM in K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa and A549, respectively; and had low cytotoxicity in normal cells MRC-5 with an IC₅₀ over 100 μM.

分子量

362.33

Formula

C₁₈H₁₈O₈

CAS 号

1003600-48-3

结构分类

Ketones, Aldehydes, Acids

初始来源

植物
番荔枝科
Cleistochlamys kirkii Oliver

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (528 KB) 产品使用指南 (1538 KB)

参考文献

[1]. Benedeković G, et al. Synthesis, antiproliferative activity and SAR analysis of (-)-cleistenolide and analogues. Eur J Med Chem. 2020;202:112597. [Content Brief]

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