Illudin M

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Illudin M 

Illudin M 是一种细胞毒性真菌倍半萜，可以从 Omphalotus illudens 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。

Illudin M

Illudin M Chemical Structure

CAS No. : 1146-04-9

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生物活性

Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities[1][2].

体外研究
(In Vitro)

Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Illudin M 相关抗体:

Apoptosis Analysis[1]

Cell Line: Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs)
Concentration: 0.01 μM, 1 μM, 10 μM
Incubation Time: 24 hours, 48 hours,72 hours, 96 hours, 120 hours
Result: Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).

分子量

248.32

Formula

C15H20O3
CAS 号

1146-04-9
结构分类
  • Terpenoids
  • Sesquiterpenes
初始来源
  • 微生物

Omphalotus illudens
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Rainer Schobert, et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorg Med Chem. 2008 Sep 15;16(18):8592-7.  [Content Brief]

    [2]. Dr. Philipp Le, et al. A Chemical Proteomic Analysis of Illudin‐Interacting Proteins. Chemistry. 2019 Sep 25; 25(54): 12644–12651.  [Content Brief]

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