Phenylbutazone(diphenyl-d10)(Synonyms: 保泰松 d10)

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Phenylbutazone(diphenyl-d10) (Synonyms: 保泰松 d10)

Phenylbutazone-d10 (diphenyl) 是 Phenylbutazone 的氘代物。Phenylbutazone 是有效的前列腺素 H 合酶 (PHS) 过氧化物酶的还原辅助因子。Phenylbutazone 是一种肝毒素，是非甾体类抗炎药 (NSAID)。Phenylbutazone 诱导肌肉盲样蛋白1 (MBNL1) 表达，有用于强直性脊柱炎研究的潜力。

Phenylbutazone(diphenyl-d10)(Synonyms: 保泰松 d10)

Phenylbutazone(diphenyl-d10) Chemical Structure

CAS No. : 1219794-69-0

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生物活性

Phenylbutazone-d10 (diphenyl) is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

318.44

Formula

C19H10D10N2O2
CAS 号

1219794-69-0
中文名称

保泰松 d10
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14.

    [3]. Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317.

    [4]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6.

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