Allopregnanolone-d4 is the deuterium labeled Allopregnanolone. Allopregnanolone (Brexanolone), a metabolite of progesterone, is a positive allosteric modulator of GABA_A receptors. Allopregnanolone modulates dopamine levels in the nucleus accumbens and prefrontal cortex. Allopregnanolone stimulates food intake and weight gain^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

322.52

C₂₁H₃₀D₄O₂

203805-85-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Dornellas APS, et al. Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage. Front Pharmacol. 2021;11:608887. Published 2021 Jan 14.

  [3]. Kimball A, et al. The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause. Psychoneuroendocrinology. 2020;112:104512.