L-Phenylalanine-13C9,d8,15N(Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C9,d8,15N)

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L-Phenylalanine-13C9,d8,15N (Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C9,d8,15N)

L-Phenylalanine-13C9,d8,15N ((S)-2-Amino-3-phenylpropionic acid-13C9,d8,15N) 是带有 13C，15N 标记和氘代标记的 L-Phenylalanine。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Phenylalanine 是 NMDARs (KB 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。

L-Phenylalanine-13C9,d8,15N(Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C9,d8,15N)

L-Phenylalanine-13C9,d8,15N Chemical Structure

CAS No. : 1994331-22-4

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生物活性

L-Phenylalanine-13C9,d8,15N ((S)-2-Amino-3-phenylpropionic acid-13C9,d8,15N) is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

183.17

Formula

13C9H3D815NO2
CAS 号

1994331-22-4
中文名称

L-苯丙氨酸 13C9,d8,15N
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

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