Nitroxoline-D4(Synonyms: 8-Hydroxy-5-nitroquinoline-D4; 5-Nitro-8-quinolinol-D4)

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Nitroxoline-D4 (Synonyms: 8-Hydroxy-5-nitroquinoline-D4; 5-Nitro-8-quinolinol-D4)

Nitroxoline-D4 (8-Hydroxy-5-nitroquinoline-D4) 是 Nitroxoline 的氘代物。Nitroxoline是一种抗生素, 有效防治生物膜感染, Nitroxoline通过从生物膜基质螯合Fe2+和Zn2+离子而发挥作用。

Nitroxoline-D4(Synonyms: 8-Hydroxy-5-nitroquinoline-D4; 5-Nitro-8-quinolinol-D4)

Nitroxoline-D4 Chemical Structure

规格 价格 是否有货
1 mg ￥5200 询问价格 & 货期
5 mg ￥14800 询问价格 & 货期

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生物活性

Nitroxoline-D4 (8-Hydroxy-5-nitroquinoline-D4) is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

194.18

Formula

C9H2D4N2O3
中文名称

硝羟喹啉 D4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Abouelhassan Y, et al. Nitroxoline: a broad-spectrum biofilm-eradicating agent against pathogenic bacteria. Int J Antimicrob Agents. 2017 Feb;49(2):247-251.

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