CXCR4 probe 1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
CXCR4 probe 1 

CXCR4 probe 1 (compound 5) 是一种有效且具有特异性的 CXCR4 靶向 PET 示踪剂，对 CXCR4 特异性拮抗剂 TN14003 的 IC50 为 6.9 nM。CXCR4 probe 1 有可能作为 CXCR4 特异性成像探针，用于炎性疾病、CXCR4 阳性肿瘤和转移性肿瘤的诊断和预后监测。

CXCR4 probe 1

CXCR4 probe 1 Chemical Structure

CAS No. : 2077985-50-1

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生物活性

CXCR4 probe 1 (compound 5) is a potent and specific CXCR4-targeted PET tracer with an IC50 value of 6.9 nM against CXCR4-specific antagonist peptide, TN14003. CXCR4 probe 1 has potential to be used as CXCR4-specific imaging probe to diagnose and monitor the prognosis of inflammatory diseases, CXCR4-positive tumors, and metastatic cancers[1].

IC50 & Target[1]

CXCR4

 

体内研究
(In Vivo)

CXCR4 probe 1 displays preferential accumulation in lung metastatic tumors and specifically binds to CXCR4-positive stem cells in bone marrow[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

502.59

Formula

C24H3018FN5O4S
CAS 号

2077985-50-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (478 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Oum YH, et al. A benzenesulfonamide derivative as a novel PET radioligand for CXCR4. Bioorg Med Chem. 2020 Jan 15;28(2):115240.

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