Lewis y tetrasaccharide (Synonyms: Lewis y)

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Lewis y tetrasaccharide  (Synonyms: Lewis y) 纯度: ≥99.0%

Lewis Y tetrasaccharide (Lewis Y, LeY) 是 Lewis X trisaccharide (HY-N10534) 的四糖衍生物。Lewis Y tetrasaccharide 是一种与恶性卵巢癌转移和预后不良相关的抗原。

Lewis y tetrasaccharide (Synonyms: Lewis y)

Lewis y tetrasaccharide Chemical Structure

CAS No. : 82993-43-9

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1 mg ￥4480 In-stock
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Lewis y tetrasaccharide 相关产品

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生物活性

Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis[1][2].

体外研究
(In Vitro)

Lewis Y tetrasaccharide activates FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression to enhance cell adhesion mediated drug resistance (CAM-DR) in ovarian cancer cells[1].
Lewis Y tetrasaccharide results in integrin α5β1 level increase in ovarian carcinoma-derived cells exhibiting enhanced expression of LeY (RMG-1-hFUT)[2].
Lewis Y tetrasaccharide enhances the adhesive and spreading potentials mediated by the integrin-fibronectin interaction of ovarian carcinoma RMG-1 cells[2].
Anti-LeY antibodies (10 μg/mL; 37 ℃; 24 h) significantly inhibits the proliferation and adhesion ability of RMG-1-hFUT cells cultured in vivo[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Lewis y tetrasaccharide 相关抗体:
分子量

675.63

Formula

C26H45NO19
CAS 号

82993-43-9
性状

固体

颜色

White to off-white

结构分类
  • Saccharides
  • Polysaccharides
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (536 KB) SDS (251 KB)

COA (276 KB) 元素分析报告 (221 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Yan LM, et al. Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin alpha5beta1 with the Lewis Y-structure on transfection of the alpha1,2-fucosyltransferase gene. Biochimie. 2010 Jul;92(7):852-7.   [Content Brief]

    [2]. Yan L, et al. Lewis y enhances CAM-DR in ovarian cancer cells by activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression. Biochimie. 2015 Jun;113:17-25.   [Content Brief]

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