Nepodin (Synonyms: Musizin)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Nepodin  (Synonyms: Musizin) 纯度: 99.71%

Nepodin (Musizin) 是一种醌氧化还原酶 (PfNDH2) 抑制剂，从 Rumex crispus 中分离。Nepodin (Musizin) 通过激活 AMPK 刺激 GLUT4 向质膜的转运。Nepodin (Musizin) 具有抗糖尿病和抗疟疾的作用。

Nepodin (Synonyms: Musizin)

Nepodin Chemical Structure

CAS No. : 3785-24-8

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5 mg ￥1600 In-stock
10 mg ￥2600 In-stock
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生物活性

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Nepodin 相关抗体:
体内研究
(In Vivo)

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/KsJ-db/db mice[2]
Dosage: 2 mg/kg; 10 mg/kg
Administration: Orally administration; 2-10 mg/kg; 4 weeks
Result: Had antihyperglycemic potential and improved insulin resistance.

分子量

216.23

Formula

C13H12O3
CAS 号

3785-24-8
性状

固体

颜色

White to yellow

结构分类
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 蓼科
  • 羊蹄
  • 植物
  • 蓼科
  • 皱叶酸模
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (578.09 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.6247 mL 23.1235 mL 46.2471 mL
5 mM 0.9249 mL 4.6247 mL 9.2494 mL
10 mM 0.4625 mL 2.3124 mL 4.6247 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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纯度 & 产品资料

纯度: 99.71%

Data Sheet (604 KB) SDS (393 KB)

COA (269 KB) HNMR (277 KB) LCMS (265 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Lee KH, et al. Antimalarial activity of nepodin isolated from Rumex crispus. Arch Pharm Res. 2013 Apr;36(4):430-5.  [Content Brief]

    [2]. Ha BG, et al. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47.  [Content Brief]

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