Eleutheroside B1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Eleutheroside B1  纯度: 98.73%

Eleutheroside B1,香豆素化合物,具有广谱的抗人流感病毒 (influenza virus) 作用,其IC50 值为 64-125μg/ml。Eleutheroside B1 通过 POLR2A 和 N-糖基化介导其抗流感活性。Eleutheroside B1 抑制多种趋化因子基因和流感病毒核蛋白 (NP) 基因的 mRNA 表达,且具有较低的细胞毒性。具有抗病毒、抗炎活性。

Eleutheroside B1

Eleutheroside B1 Chemical Structure

CAS No. : 16845-16-2

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Eleutheroside B1 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

同靶点产品:

同靶点蛋白产品:

生物活性

Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities[1].

体外研究
(In Vitro)

Eeutheroside B1 (100 µg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Eleutheroside B1 相关抗体:

RT-PCR[1]

Cell Line: Virus-infected A549 cells
Concentration: 100 µg/ml
Incubation Time: 24 hours
Result: The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased.

分子量

384.33

Formula

C17H20O10

CAS 号

16845-16-2

性状

固体

颜色

White to off-white

结构分类
  • Phenylpropanoids
  • Coumarins
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: 98.73%

Data Sheet (537 KB) SDS (251 KB)

COA (203 KB) RP-HPLC (268 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Yan W, et al. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.Int J Mol Med. 2018 Nov;42(5):2776-2792.  [Content Brief]

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