Dihydrochelerythrine (Synonyms: 二氢白屈菜红碱; 12,13-Dihydrochelerythrine)

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Dihydrochelerythrine  (Synonyms: 二氢白屈菜红碱; 12,13-Dihydrochelerythrine) 纯度: 99.17%

二氢白屈菜红碱(Dihydrochelerythrine)是从延胡索分离出的天然化合物，具抗真菌等活性。

Dihydrochelerythrine (Synonyms: 二氢白屈菜红碱; 12,13-Dihydrochelerythrine)

Dihydrochelerythrine Chemical Structure

CAS No. : 6880-91-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1650 In-stock
5 mg ￥1500 In-stock
10 mg ￥2400 In-stock
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Dihydrochelerythrine 相关产品

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生物活性

Dihydrochelerythrine is a natural compound isolated from Corydalis yanhusuo; has antifungal activity. IC50 value: Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].

分子量

349.38

Formula

C21H19NO4
CAS 号

6880-91-7
性状

固体

颜色

White to off-white

中文名称

二氢白屈菜红碱
结构分类
  • Alkaloids
  • Quinoline Alkaloids
初始来源
  • 植物
  • 罂粟科
  • 博落回
  • 植物
  • 罂粟科
  • 延胡索
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 20.83 mg/mL (59.62 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8622 mL 14.3111 mL 28.6221 mL
5 mM 0.5724 mL 2.8622 mL 5.7244 mL
10 mM 0.2862 mL 1.4311 mL 2.8622 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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浓度

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This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

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体积 (start)

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浓度 (final)

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体积 (final)

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动物溶解方案

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给药剂量

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纯度 & 产品资料

纯度: 99.39%

Data Sheet (597 KB) SDS (393 KB)

COA (264 KB) HNMR (180 KB) LCMS (350 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9.  [Content Brief]

    [2]. Vrba J, et al. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells. Toxicol In Vitro. 2008 Jun;22(4):1008-17.  [Content Brief]

    [3]. Tantapakul C, et al. Antibacterial compounds from Zanthoxylum rhetsa. Arch Pharm Res. 2012 Jul;35(7):1139-42.  [Content Brief]

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