Sterigmatocystine (Synonyms: 甾体半胱氨酸)

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Sterigmatocystine  (Synonyms: 甾体半胱氨酸) 纯度: 99.74%

Sterigmatocystine 是黄曲霉素的前体，是由 Aspergillus versicolor 产生的一种霉菌素。 Sterigmatocystine 是 G1 期和 DNA 合成的抑制剂，用于抑制 p21 活性。Sterigmatocystine 对动物发育具有致畸和致癌作用。

Sterigmatocystine (Synonyms: 甾体半胱氨酸)

Sterigmatocystine Chemical Structure

CAS No. : 10048-13-2

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1 mg ￥2036 In-stock
5 mg ￥3500 In-stock
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Sterigmatocystine 相关产品

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生物活性

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor[1][2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals[3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Sterigmatocystine 相关抗体:
体内研究
(In Vivo)

Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

324.28

Formula

C18H12O6
CAS 号

10048-13-2
性状

固体

颜色

Light yellow to yellow

中文名称

甾体半胱氨酸
结构分类
  • Phenols
  • Monophenols
  • Phenols
  • Xanthones
初始来源
  • 微生物

Aspergillus versicolor
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 25 mg/mL (77.09 mM; 超声助溶 (<80°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0838 mL 15.4188 mL 30.8375 mL
5 mM 0.6168 mL 3.0838 mL 6.1675 mL
10 mM 0.3084 mL 1.5419 mL 3.0838 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

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体积 (start)

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浓度 (final)

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体积 (final)

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

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动物的平均体重

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工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.74%

Data Sheet (608 KB) SDS (584 KB)

COA (182 KB) HNMR (102 KB) RP-HPLC (97 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16(4):224-31.  [Content Brief]

    [2]. Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30(4):589-91.  [Content Brief]

    [3]. Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42(4):1645-1656.  [Content Brief]

    [4]. Zhang D, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8(5):e65044.  [Content Brief]

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