Arnicolide D (Synonyms: 山金车内酯 D)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Arnicolide D  (Synonyms: 山金车内酯 D) 纯度: 99.20%

Arnicolide D 是一种从石胡荽 (Centipeda minima) 中分离出倍半萜内酯。Arnicolide D 调节细胞周期,激活 caspase 信号通路,并抑制 PI3K/AKT/mTORSTAT3 信号通路。Arnicolide D 以剂量和时间依赖性方式显着抑制鼻咽癌 (NPC) 细胞生长。

Arnicolide D                                          (Synonyms: 山金车内酯 D)

Arnicolide D Chemical Structure

CAS No. : 34532-68-8

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生物活性

Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner[1].

IC50 & Target[1]

Caspase

 

PI3K

 

mTOR

 

STAT3

 

分子量

332.39

Formula

C19H24O5

CAS 号

34532-68-8

性状

固体

颜色

White to off-white

中文名称

山金车内酯 D

结构分类
  • Terpenoids
  • Sesquiterpenes
初始来源
  • 植物
  • 豆科
  • 伏毛山豆根
  • 植物
  • 菊科
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 25 mg/mL (75.21 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0085 mL 15.0426 mL 30.0851 mL
5 mM 0.6017 mL 3.0085 mL 6.0170 mL
10 mM 0.3009 mL 1.5043 mL 3.0085 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

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纯度 & 产品资料

纯度: 99.20%

Data Sheet (605 KB) SDS (251 KB)

COA (270 KB) HNMR (97 KB) CNMR (86 KB) RP-HPLC (198 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Liu R, et al. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules. 2019 May 17;24(10).  [Content Brief]

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