Apoptolidin | Axygen爱思进官网

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Apoptolidin 纯度: ≥95.0%

Apoptolidin 是从 Nocardiopsis 细菌中分离得到的一种聚酮类化合物。Apoptolidin 是一种选择性线粒体 F₁F_O ATPase 抑制剂。Apoptolidin 是一种凋亡 (apoptosis)诱导剂，可诱导腺病毒型 12 癌基因(包括ElA) (IC₅₀=10-17 ng/ml) 转化的细胞凋亡，但不诱导正常细胞的凋亡。

Apoptolidin Chemical Structure

CAS No. : 194874-06-1

规格	价格	是否有货	数量
100 μg	￥6500	In-stock

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Apoptolidin 相关产品

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生物活性

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria^[1]. Apoptolidin is a selective mitochondrial F₁F_O ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC₅₀=10-17 ng/ml) but not in normal cells^[1]^[2].

体外研究
(In Vitro)

Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC₅₀ values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptolidin 相关抗体:

分子量

1129.37

Formula

C₅₈H₉₆O₂₁

CAS 号

194874-06-1

性状

固体

颜色

White to off-white

结构分类

Others

初始来源

微生物

Nocardiopsis

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度 & 产品资料

纯度: ≥95.0%

选择批次：

Data Sheet (543 KB) SDS (251 KB)

COA (176 KB)

产品使用指南 (1538 KB)

参考文献

[1]. J W Kim, et al. Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. J Antibiot (Tokyo). 1997 Jul;50(7):628-30. [Content Brief]

[2]. A R Salomon, et al. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14766-71. [Content Brief]

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