20(R)-Ginsenoside Rh2 (Synonyms: 20(R)-人参皂苷Rh2)

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20(R)-Ginsenoside Rh2  (Synonyms: 20(R)-人参皂苷Rh2) 纯度: ≥98.0%

20(R)-Ginsenoside Rh2，基质金属蛋白酶 (MMP) 抑制剂，作为细胞抗增殖剂。它通过阻断细胞增殖和引起 G1 期阻滞而具有抗癌作用。20(R)-Ginsenoside Rh2 诱导细胞凋亡并具有抗炎和抗氧化活性。20(R)-Ginsenoside Rh2 抑制小鼠和人 γ 疱疹病毒 68 (MHV-68) 的复制和增殖，对鼠 MHV-68 的 IC50 为 2.77 μM。

20(R)-Ginsenoside Rh2 (Synonyms: 20(R)-人参皂苷Rh2)

20(R)-Ginsenoside Rh2 Chemical Structure

CAS No. : 112246-15-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2672 In-stock
1 mg ￥723 In-stock
5 mg ￥1950 In-stock
10 mg ￥3200 In-stock
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100 mg   询价  

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生物活性

20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3]. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC50 of 2.77 μM for murine MHV-68[4].

IC50 & Target

MMP[1]
分子量

622.87

Formula

C36H62O8
CAS 号

112246-15-8
性状

固体

颜色

White to off-white

中文名称

20(R)-人参皂苷Rh2
结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 五加科
  • 人参
  • 内源性代谢物
  • 人肠道微生物代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (200.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6055 mL 8.0274 mL 16.0547 mL
5 mM 0.3211 mL 1.6055 mL 3.2109 mL
10 mM 0.1605 mL 0.8027 mL 1.6055 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (607 KB) SDS (251 KB)

COA (266 KB) HNMR (283 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6.  [Content Brief]

    [2]. Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40.  [Content Brief]

    [3]. Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8.  [Content Brief]

    [4]. Kang S, et al. Antiviral activity of 20(R)-ginsenoside Rh2 against murine gammaherpesvirus. J Ginseng Res. 2017 Oct;41(4):496-502.  [Content Brief]

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