Delphinidin 3-glucoside chloride (Synonyms: 氯化飞燕草素葡萄糖苷; Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride)

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Delphinidin 3-glucoside chloride  (Synonyms: 氯化飞燕草素葡萄糖苷; Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride) 纯度: 99.67%

Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) 是在 Hibiscus sabdariffa 提取物中发现的一种活性花色苷。Delphinidin 3-glucoside chloride 诱导 B 细胞慢性淋巴细胞性白血病 (B CLL) 的促凋亡作用。Delphinidin 3-glucoside chloride 通过结合 ERβ 发挥植物雌激素活性，IC50 为 9.7 μM。Delphinidin-3-O-glucoside chloride 抑制 EGFR，IC50 为 2.37 µM。Delphinidin 3-glucoside chloride 通过调节 pAKT/IRF1/HOTAIR 通路表达抗肿瘤活性。Delphinidin 3-glucoside chloride 具有抗氧化活性，抑制血小板聚集和内皮细胞功能障碍。

Delphinidin 3-glucoside chloride (Synonyms: 氯化飞燕草素葡萄糖苷; Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride)

Delphinidin 3-glucoside chloride Chemical Structure

CAS No. : 6906-38-3

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5 mg ￥3100 In-stock
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生物活性

Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL)[1]. Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM[2]. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 µM[3]. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction[4][5][6].

IC50 & Target

IC50: 2.37 µM (EGFR)[3]
体外研究
(In Vitro)

Delphinidin 3-glucoside chloride (30-100 μM) 通过对氧化还原敏感的 caspase 3 激活诱导 B CLL 细胞凋亡 (apoptosis)[1]。
Delphinidin 3-glucoside chloride (0-40 μM) 通过 pAKT/IRF1 信号通路下调 HOTAIR 表达，对乳腺癌细胞和致癌物诱导的乳腺癌发生具有抑制活性[4]。
Delphinidin 3-glucoside chloride (1-100 μM) 通过钠依赖型葡萄糖转运蛋白 (SGLT1) 抑制 oxLDL 诱导的 HUVEC 内皮功能障碍[5]。
Delphinidin 3-glucoside chloride (0-50 μM) 通过抑制 AMPK 磷酸化来抑制 ADP、胶原蛋白或 TRAP 刺激引起的血小板聚集[6]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Delphinidin 3-glucoside chloride 相关抗体:

Apoptosis Analysis[1]

Cell Line: B CLLs
Concentration: 30-100 μM
Incubation Time: 24 h
Result: Induced cell apoptosis.

Western Blot Analysis[4]

Cell Line: MDA-MB-231 and MCF-7, HUVECs, B CLLs
Concentration: 40 μM for MDA-MB-231 and MCF-7, 0-100 μM for HUVECS
Incubation Time: 24 h
Result: Inhibited AKT phosphorylation.
Increased levels of pro-apoptotic factors: Cyt c, caspase 3 and Bax, decreased levels of Bcl-2.

Immunofluorescence[4]

Cell Line: MDA-MB-231
Concentration: 0-40 μM
Incubation Time: 24 h
Result: Promoted IRF1 expression.

体内研究
(In Vivo)

Delphinidin 3-glucoside chloride (40 mg/kg/day，灌胃，25 天) 抑制 MDA-MB-231-Luc-GFP 异种移植的无胸腺 BALB/c 小鼠的肿瘤生长[4]。 Delphinidin 3-glucoside chloride (50 μM，静脉注射) 抑制 FeCl3 诱导的 C57BL/6 小鼠肠系膜小动脉损伤时的血栓生长[6]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA-MB-231-Luc-GFP xenografted athymic BALB/c mice[4]
Dosage: 40 mg/kg/day
Administration: i.g., for 25 days
Result: Inhibited tumor growth.

分子量

500.84

Formula

C21H21ClO12
CAS 号

6906-38-3
性状

固体

颜色

Purple to black

中文名称

氯化飞燕草素葡萄糖苷；氯化飞燕草素-3-O-葡萄糖苷
结构分类
  • Flavonoids
  • Anthocyans
初始来源
  • 植物
  • 锦葵科
  • 玫瑰茄
  • 微生物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (19.97 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9966 mL 9.9832 mL 19.9665 mL
5 mM 0.3993 mL 1.9966 mL 3.9933 mL
10 mM 0.1997 mL 0.9983 mL 1.9966 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

In Vivo:

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.5 mg/mL (1.00 mM); 澄清溶液

    此方案可获得 ≥ 0.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。

  • 方案 二

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.5 mg/mL (1.00 mM); 澄清溶液

    此方案可获得 ≥ 0.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

    20% SBE-β-CD in Saline 的配制（4°C，储存一周）：2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：
%

DMSO +

% 

%

Tween-80 +

%

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO， ，均可在 Shanghai Jinpan Biotech Co Ltd 网站选购。 ，Tween 80，均可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

计算结果
工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

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动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.83%

Data Sheet (638 KB) SDS (393 KB)

COA (276 KB) HNMR (408 KB) CNMR (427 KB) RP-HPLC (375 KB) MS (1546 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Mahmoud Alhosin, et al. Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway. Sci Rep. 2015 Mar 11;5:8996.  [Content Brief]

    [2]. Naoki Nanashima, et al. Phytoestrogenic Activity of Blackcurrant Anthocyanins Is Partially Mediated through Estrogen Receptor Beta. Molecules. 2017 Dec 29;23(1):74.  [Content Brief]

    [3]. Candice Mazewski, et al. Comparison of the effect of chemical composition of anthocyanin-rich plant extracts on colon cancer cell proliferation and their potential mechanism of action using in vitro, in silico, and biochemical assays. Food Chem. 2018 Mar 1;242:378-388.  [Content Brief]

    [4]. Yang X, et al., Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway. BMC Cancer. 2016 Jul 7;16:423.  [Content Brief]

    [5]. Jin X, et al., Delphinidin-3-glucoside protects against oxidized low-density lipoprotein-induced mitochondrial dysfunction in vascular endothelial cells via the sodium-dependent glucose transporter SGLT1. PLoS One. 2013 Jul 18;8(7):e68617.  [Content Brief]

    [6]. Yang Y, et al., Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: novel protective roles against cardiovascular diseases. PLoS One. 2012;7(5):e37323.  [Content Brief]

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