Cirsilineol (Synonyms: 甲基条叶蓟素)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Cirsilineol (Synonyms: 甲基条叶蓟素) 纯度: ≥98.0%

Cirsilineol 是一种天然黄酮化合物，可选择性抑制肠道 CD4⁺ T 细胞中的 IFN-γ/STAT1/T-bet 信号。Cirsilineol 具有免疫抑制和抗肿瘤特性。Cirsilineol 显着改善三硝基苯磺酸 (TNBS) 诱导的小鼠 T 细胞介导的实验性结肠炎。

Cirsilineol Chemical Structure

CAS No. : 41365-32-6

规格	价格	是否有货
1 mg	￥4200	In-stock
5 mg		询价
10 mg		询价

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Cirsilineol 相关产品

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生物活性

Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4⁺ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice^[1].

体外研究
(In Vitro)

Cirsilineol (0.1-10 μM；96 小时) 以剂量依赖性方式抑制单个混合淋巴细胞反应和 Concanava A 诱导的 T 细胞增殖。Cirsilineol (10 μM) 不影响 T 淋巴细胞的活力。cirsilineol (10 μM) 对 T 细胞增殖的抑制不是由于细胞毒活性^[1]。
Cirsilineol (1-10 μM；预处理 3 小时) 完全抑制 IFN-γ 诱导的 Tyr701 磷酸化 STAT1 和 JAK2 激活^[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cirsilineol 相关抗体:

Cell Proliferation Assay^[1]

Cell Line:	Splenocytes
Concentration:	0.1, 1, 10 μM
Incubation Time:	96 hours
Result:	Inhibited single mixed lymphocyte reaction and Concanavalin A (Con A; 5 μg/mL; for 72 h)-induced T-cell proliferation in a dose-dependent manner. Suppressed OVA_323-339-specific CD4⁺ T-cell proliferation.

Western Blot Analysis^[1]

Cell Line:	Splenic CD4⁺ T cells
Concentration:	1, 5, 10 μM
Incubation Time:	Pretreatment for 3 hours
Result:	Completely inhibited IFN-γ-induced (25 ng; 30 mins) Tyr701 phosphorylation of STAT1 and JAK2 activation. Suppressed IFN-γ-induced (25 ng; 12 hours) Th1-specific transcription factor T-bet.

体内研究
(In Vivo)

cirsilineol (3、10 和 30 mg/kg) 通过抑制 CD4⁺ T 细胞中的 IFN-γ/STAT1/T-bet 信号显著改善 TNBS 诱导的 Th1 介导的结肠炎。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10-week-old female C57BL/6, BALB/c and DO11.10 transgenic mice with TNBS (10 mg; 100 μL)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	IP; daily; for 11 days
Result:	Showed a significant improved effect on the body weights and survival rate of mice. Markedly reduced inflammatory infiltration, restoration of the destructive mucosal architecture and remission of edema.

分子量

344.32

Formula

C₁₈H₁₆O₇

CAS 号

41365-32-6

性状

固体

颜色

White to light yellow

中文名称

甲基条叶蓟素

结构分类

Flavonoids
Flavones

Phenols
Monophenols

初始来源

植物
豆科
毒豆

植物
菊科

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (537 KB) SDS (251 KB)

COA (193 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Yang Sun, et al. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. Biochem Pharmacol. 2010 Jan 15;79(2):229-38. [Content Brief]

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