Isolinderalactone

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Isolinderalactone  纯度: 98.79%

Isolinderalactone 通过抑制内皮细胞 VEGFR2 活化，抑制人胶质母细胞瘤的生长和血管生成活性。Isolinderalactone 抑制Bcl-2， survivin和XIAP的表达，增加 cleaved caspase-3 的水平。

Isolinderalactone

Isolinderalactone Chemical Structure

CAS No. : 957-66-4

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1 mg ￥960 In-stock
5 mg ￥2400 In-stock
10 mg ￥3900 In-stock
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Isolinderalactone 相关产品

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生物活性

Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells[1]. Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi

IC50 & Target

VEGFR2

 

Bcl-2

 

分子量

244.29

Formula

C15H16O3
CAS 号

957-66-4
性状

固体

颜色

White to off-white

结构分类
  • Terpenoids
  • Sesquiterpenes
初始来源
  • 植物
  • 樟科
  • 乌药
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: 98.79%

Data Sheet (536 KB) SDS (393 KB)

COA (186 KB) HNMR (223 KB) CNMR (215 KB) RP-HPLC (256 KB) MS (209 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Park JH, et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Cancer Lett. 2020;478:71-81.  [Content Brief]

    [2]. Hwang JY, et al. Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model. Cancer Lett. 2019;443:25-33.  [Content Brief]

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