Aflatoxin M1 (Synonyms: 黄曲霉毒素 M1)

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Aflatoxin M1 (Synonyms: 黄曲霉毒素 M1) 纯度: 99.43%

Aflatoxin M1 是 Aflatoxin B1 的主要代谢产物。Aflatoxin M1 是一种具有口服活性的由 Aspergillus flavus 和 Aspergillus parasiticus 产生的一种霉菌毒素。毒性顺序为 Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2。

Aflatoxin M1 Chemical Structure

CAS No. : 6795-23-9

规格	价格	是否有货	数量
100 μg	￥3200	In-stock

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生物活性

Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is an orally active mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2^[1]^[2]^[3].

体外研究
(In Vitro)

Aflatoxin M1 (0.5, 1 μg/mL, 24-72 h) 可呈时间和剂量依赖性的抑制 Caco-2 细胞的生长^[2]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Aflatoxin M1 相关抗体:

Cell Viability Assay^[2]

Cell Line:	Caco-2
Concentration:	0.01, 0.05, 0.1, 0.5, 1 μg/mL
Incubation Time:	24, 48, 72 h
Result:	Inhibited cell viability at concentrations 0.5 and 1 μg/mL.

体内研究
(In Vivo)

Aflatoxin M1 (3.5 g/kg, 灌胃, 每天一次连续 28 天) 通过改变 PRODH 和 L-脯氨酸的表达激活氧化应激，进而诱导 CD-1 小鼠下游细胞凋亡，从而引起肾毒性^[3]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD-1 mice model^[3]
Dosage:	3.5 g/kg
Administration:	i.g. once a day for 28 days
Result:	Elevated MDA level and decreased SOD, T-AOC.

分子量

328.27

Formula

C₁₇H₁₂O₇

CAS 号

6795-23-9

性状

固体

颜色

White to off-white

中文名称

黄曲霉毒素 M1

结构分类

Phenylpropanoids
Coumarins

初始来源

内源性代谢物
人肠道微生物代谢物

微生物

Aspergillus flavus and Aspergillus parasiticus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度 & 产品资料

纯度: 99.43%

选择批次：

Data Sheet (539 KB) SDS (584 KB)

COA (188 KB) RP-HPLC (465 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Kumar P, et al. Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management. Front Microbiol. 2017 Jan 17;7:2170. [Content Brief]

[2]. Zhang J, et al. Aflatoxin B1 and aflatoxin M1 induced cytotoxicity and DNA damage in differentiated and undifferentiated Caco-2 cells. Food Chem Toxicol. 2015 Sep;83:54-60. [Content Brief]

[3]. Li H, et al. The Toxic Effects of Aflatoxin B1 and Aflatoxin M1 on Kidney through Regulating L-Proline and Downstream Apoptosis. Biomed Res Int. 2018 Aug 12;2018:9074861. [Content Brief]

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