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Moringin (Synonyms: 辣木籽素) 纯度: 99.95%
Moringin 是一种有效的选择性 TRPA1 离子通道天然激动剂,EC50 为 3.14 μM。Moringin 不会激活或非常微弱地激活香草素体感通道 TRPV1、TRPV2、TRPV3 和 TRPV4,以及褪黑素冷却受体 TRPM8。Moringin 具有降血糖、抗菌、抗炎、抗癌和神经保护活性。
Moringin Chemical Structure
CAS No. : 73255-40-0
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5 mg | ¥4100 | In-stock | |
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Moringin 相关产品
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生物活性 |
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities[1][2]. |
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体外研究 (In Vitro) |
在 SH-SY5Y 人神经母细胞瘤细胞中,Moringin(16.4 µM;24-72 小时)以时间和浓度依赖性方式显着降低 SH-SY5Y 细胞生长[2]。 Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
在实验性自身免疫性脑脊髓炎 (EAE) 小鼠中,Moringin (10 mg/kg;腹腔注射;每天 1 次,共 5 周) 预处理可使异常的 Wnt-β-catenin 通路正常化,导致 GSK3β 抑制和 β-catenin 上调,从而调节 T 细胞活化 ( CD4 和 FoxP3),通过激活 PPARγ 抑制主要的炎症介质 (IL-1β、IL-6 和 COX2)。 辣木苷增加 EAE 小鼠体内抗氧化 Nrf2 的表达[3]。 Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
311.35 |
Formula |
C14H17NO5S |
CAS 号 |
73255-40-0 |
性状 |
固体 |
颜色 |
White to light yellow |
中文名称 |
辣木籽素 |
结构分类 |
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初始来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
纯度 & 产品资料 |
纯度: 99.95%
Data Sheet (533 KB) SDS (479 KB)
COA (190 KB) RP-HPLC (172 KB) 产品使用指南 (1538 KB) |
参考文献 |
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