Hydroxypyruvic acid (Synonyms: β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid)

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Hydroxypyruvic acid  (Synonyms: β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid) 纯度: ≥98.0%

Hydroxypyruvic acid (β-Hydroxypyruvic acid) 是甘氨酸、丝氨酸和苏氨酸代谢的中间产物 (intermediate)。Hydroxypyruvic acid 是丝氨酸-丙酮酸氨基转移酶和乙醛酸还原酶/羟基丙酮酸还原酶的底物 (substrate)。Hydroxypyruvic acid 参与了二甲基甘氨酸脱氢酶缺乏症的代谢紊乱途径。

Hydroxypyruvic acid (Synonyms: β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid)

Hydroxypyruvic acid Chemical Structure

CAS No. : 1113-60-6

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1 mg ￥1250 In-stock
5 mg ￥3650 In-stock
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生物活性

Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

IC50 & Target

Human Endogenous Metabolite

 

体内研究
(In Vivo)

Hydroxypyruvic acid (intravenous injection; 100 mg/ml; slowly over 10 min) increases the 5-h urinary oxalate and glycolate excretion to 0.68% (6.56 μmol) and 0.53% (5.10 μmol) in control rats, in addition, it increases to 2.43% (23.36 μmol) and 0.79% (7.59 μmol) of the dose in the vitamin-B6-deficient rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rat[1]
Dosage: 100 mg/ml; slowly over 10 min
Administration: Intravenous injection
Result: Led to a significant increase of urinary oxalate and glycolate excretion in both control and vitamin-B6-deficient rats, but these changes are exaggerated in the vitamin-B6-deficient group.

分子量

104.06

Formula

C3H4O4
CAS 号

1113-60-6
性状

固体

颜色

Off-white to light brown

中文名称

羟基丙酮酸
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
  • 人肠道微生物代谢物
  • 微生物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : 40 mg/mL (384.39 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 9.6098 mL 48.0492 mL 96.0984 mL
5 mM 1.9220 mL 9.6098 mL 19.2197 mL
10 mM 0.9610 mL 4.8049 mL 9.6098 mL

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

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体积 (start)

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浓度 (final)

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体积 (final)

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纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (598 KB) SDS (416 KB)

COA (189 KB) 元素分析报告 (206 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Teerajetgul Y, et al. Oxalate synthesis from hydroxypyruvate in vitamin-B6-deficient rats.Urol Res. 2007 Aug;35(4):173-8. Epub 2007 Jun 13.  [Content Brief]

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