Cytostatin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Cytostatin 

Cytostatin 是一种有效的、选择性的 PP2A 抑制剂，具有良好的抗肿瘤活性。Cytostatin 也是细胞与细胞外基质粘附的抑制剂，可诱导细胞凋亡 (apoptosis)。细胞抑制素属于天然产物 fosriecin 家族。

Cytostatin

Cytostatin Chemical Structure

CAS No. : 682329-63-1

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生物活性

Cytostatin is a potent and selective inhibitor of PP2A with promising antitumor activity. Cytostatin is also an inhibitor of cell adhesion to extracellular matrix and induces cell apoptosis. Cytostatin belongs to the fostriecin family of natural products[1][2][3].

IC50 & Target

PP2A[1]
分子量

428.46

Formula

C21H33O7P
CAS 号

682329-63-1
结构分类
  • Others
初始来源
  • 微生物

fostriecin
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (525 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Lawhorn BG, et al. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. J Am Chem Soc. 2006;128(51):16720-16732.  [Content Brief]

    [2]. Kawada M, et al. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim Biophys Acta. 1999;1452(2):209-217.  [Content Brief]

    [3]. Kawada M, et al. Differential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin. Jpn J Cancer Res. 1999;90(2):219-225.  [Content Brief]

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