Niacin hydrochloride (Synonyms: B3维生素; Nicotinic acid hydrochloride; Vitamin B3 hydrochloride)

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Niacin hydrochloride  (Synonyms: B3维生素; Nicotinic acid hydrochloride; Vitamin B3 hydrochloride)

Niacin (Vitamin B3; Nicotinic acid) hydrochloride 是一种具有口服活性的 B3 维生素 (B3 vitamin)，是人类必需的营养物质。Niacin hydrochloride 在能量代谢、细胞信号级联调节基因表达和细胞凋亡 (apoptosis) 中起关键作用，也可用于心血管疾病的研究。

Niacin hydrochloride (Synonyms: B3维生素; Nicotinic acid hydrochloride; Vitamin B3 hydrochloride)

Niacin hydrochloride Chemical Structure

CAS No. : 636-79-3

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Niacin hydrochloride 的其他形式现货产品:

Niacin

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生物活性

Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism[1].
Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Niacin hydrochloride 相关抗体:

RT-PCR[1]

Cell Line: Cumulus cells and oocytes of prepubertal gilts
Concentration: 600 μM
Incubation Time: 42 hours
Result: Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX.

Cell Proliferation Assay[2]

Cell Line: Rat ascites hepatoma cell line of AH109A
Concentration: 0-40 μM
Incubation Time: 24 hours
Result: Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.

体内研究
(In Vivo)

Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice[3]
Dosage: 3-300 mg/kg
Administration: Subcutaneous injection; once
Result: Induced vasodilation in a dose-dependent manner.

Clinical Trial

分子量

159.57

Formula

C6H6ClNO2
CAS 号

636-79-3
中文名称

B3维生素
结构分类
  • Alkaloids
  • Pyridine Alkaloids
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (539 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18.  [Content Brief]

    [2]. Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8.  [Content Brief]

    [3]. Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7.  [Content Brief]

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