Octacosane (Synonyms: 二十八烷; n-Octacosane; NSC 5549)

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Octacosane  (Synonyms: 二十八烷; n-Octacosane; NSC 5549) 纯度: ≥98.0%

Octacosane 是一种具有抗菌活性的内源性代谢物。Octacosane 可以诱导针对移植的皮下黑色素瘤的保护作用，同时也对小鼠黑色素瘤 B16F10-Nex2 细胞显示出高细胞毒性。Octacosane 对库蚊具有杀幼虫活性，LC50 浓度为 7.2 mg/l。

Octacosane (Synonyms: 二十八烷; n-Octacosane; NSC 5549)

Octacosane Chemical Structure

CAS No. : 630-02-4

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Octacosane 相关产品

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生物活性

Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[1][2][3].

IC50 & Target[1][2][3]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Octacosane (12.5-100 μg/ml; 18 h) displays strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Octacosane 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: B16F10-Nex2 cells
Concentration: 12.5, 25, 50, 100 μg/ml
Incubation Time: 18 h
Result: Displayed strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml

体内研究
(In Vivo)

Octacosane (500 μg; injected at peripheral sites in relation to the original cell grafting; daily; 35 days) results in a significant delay of tumor progression with a significant antitumor effect[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice with B16F10-Nex2 Cellsl[1]
Dosage: 500 μg
Administration: Injected at peripheral sites in relation to the original cell grafting; daily; 35 days
Result: Resulted in a significant delay of tumor progression with a significant antitumor effect.
The survival rate of treated groups was significantly increased.

分子量

394.76

Formula

C28H58
CAS 号

630-02-4
性状

固体

颜色

White to off-white

中文名称

二十八烷
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (525 KB) SDS (0 KB)

COA (181 KB) HNMR (116 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Carlos R Figueiredo, et al. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76.  [Content Brief]

    [2]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9.  [Content Brief]

    [3]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156.  [Content Brief]

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