Cecropin A TFA (Synonyms: 抗菌肽三氟醋酸盐)

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Cecropin A TFA  (Synonyms: 抗菌肽三氟醋酸盐) 纯度: 99.00%

Cecropin A TFA 是由 37 个氨基酸残基构成的线性抗菌肽，从 Hyalaphora cecropia pupae 得到，具有抗菌、抗炎和抗癌作用。

Cecropin A TFA (Synonyms: 抗菌肽三氟醋酸盐)

Cecropin A TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1900 In-stock
5 mg ￥4900 In-stock
10 mg ￥7400 In-stock
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Cecropin A TFA 相关产品

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  • Bioactive Compound Library Plus
  • Peptide Library

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生物活性

Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. Cecropin A TFA exhibits anti-bacterial, anti-inflammatory[1] and anti-cancer activity[2].

体外研究
(In Vitro)

Cecropin A (10, 20, 30, 40 and 50 μM) induces cytotoxicity on HL-60 cells in a dose-dependent manner. Cecropin A induces apoptosis independent of caspase activation[1].
Cecropin A shows good antibacterial activity against both multidrug-resistant Gram-negative bacteria such as A. baumanii (MDRAB) and multidrug-resistant P. aeruginosa (MDRPA) with IC50s of 0.5-1 μM.
Cecropin A (0.1, 0.25 μM) exhibits anti-inflammatory activities. Cecropin A (25 μM) effectively suppresses the expression of mTNF-α, mIL-1β, and mMIP-2 mRNA and slightly inhibits the expression of mMIP-1 mRNA. Cecropin A also effectively inhibits LPS-induced phosphorylation of ERK, JNK, p38 MAPK, and reduced the expression of COX-2[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cecropin A TFA 相关抗体:
分子量

4003.78 (free base)

Formula

C184H313N53O46.xC2HF3O2
性状

固体

颜色

White to off-white

中文名称

抗菌肽三氟醋酸盐
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Disease Research
  • Anticancer
  • Antibiotics
  • Disease Research
  • Anti-inflammation/Immunoregulatory
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

Hyalaphora cecropia
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 50 mg/mL

* “≥” means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

V1

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浓度 (final)

C2

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体积 (final)

V2

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纯度 & 产品资料

纯度: 99.00%

Data Sheet (580 KB) SDS (252 KB)

COA (185 KB) RP-HPLC (252 KB) 元素分析报告 (203 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Cerón JM, et al. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides. 2010 Aug;31(8):1494-503.  [Content Brief]

    [2]. Lee E, et al. Anti-inflammatory activities of cecropin A and its mechanism of action. Arch Insect Biochem Physiol. 2015 Jan;88(1):31-44.  [Content Brief]

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