Tigloylgomisin H

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Tigloylgomisin H 

Tigloylgomisin H 是从 S. chinensis 果实中分离的一种木酚素，能诱导小鼠肝癌细胞 Hepa1c1c7 中醌还原酶 (QR) 活性。Tigloylgomisin H 是一种单功能诱导剂，通过 Nrf2-ARE 途径特异性上调 II 期解毒酶 NQO1，是潜在的肝癌预防剂。

Tigloylgomisin H

Tigloylgomisin H Chemical Structure

CAS No. : 66069-55-4

规格 价格 是否有货 数量
1 mg ￥740 1 周
5 mg ￥1800 1 周
10 mg ￥2900 1 周
50 mg   询价  
100 mg   询价  

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生物活性

Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1].

分子量

500.58

Formula

C28H36O8
CAS 号

66069-55-4
结构分类
  • Phenylpropanoids
  • Lignans
初始来源
  • 植物
  • 五味子科
  • 五味子
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (537 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.  [Content Brief]

    [2]. Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.

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