Equisetin

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Equisetin  纯度: 98.02%

Equisetin 是从陆生真菌 Fusarium equiseti NRRL 5537 中分离出的 N-甲基丝氨酸衍生的酰基特拉姆酸，它作为一种含有四联体的天然产物，具有抗生素和细胞毒活性，可以抑制革兰氏阳性菌的生长和 HIV-1 整合酶活性，但对革兰氏阴性菌没有活性。Equisetin 是一种群体感应抑制剂 (QSI)，可减弱铜绿假单胞菌中 QS 调节的毒性表型而不影响细菌的生长，是研究铜绿假单胞菌感染的主要化合物。

Equisetin

Equisetin Chemical Structure

CAS No. : 57749-43-6

规格 价格 是否有货 数量
1 mg ￥3500 In-stock
5 mg ￥8800 In-stock
10 mg   询价  
50 mg   询价  

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Equisetin 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

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•同靶点蛋白产品:

生物活性

Equisetin is an N-methylserine-derived acyl tetramic acid isolated from a terrestrial fungus Fusarium equiseti NRRL 5537[1]. Equisetin is a tetramate-containing natural product with antibiotic and cytotoxic activity[2]. Equisetin inhibits the growth of Gram-positive bacteria and HIV-1 integrase activity but shows no activity against Gram-negative bacteria[3]. Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serves as a leading compound for the treatment of P. aeruginosa infections[4].

分子量

373.49

Formula

C22H31NO4
CAS 号

57749-43-6
性状

固体

颜色

White to off-white

结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

marine fungus Fusarium sp. Z10
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.12%

Data Sheet (540 KB) SDS (251 KB)

COA (274 KB) RP-HPLC (1607 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Burmeister HR, et al. Antibiotic produced by Fusarium equiseti NRRL 5537. Antimicrob Agents Chemother. 1974 Jun;5(6):634-9.  [Content Brief]

    [2]. Vesonder RF, et al. Equisetin, an antibiotic from Fusarium equiseti NRRL 5537, identified as a derivative of N-methyl-2, 4-pyrollidone. J Antibiot (Tokyo). 1979 Jul;32(7):759-61.  [Content Brief]

    [3]. Lee J, et al. The hierarchy quorum sensing network in Pseudomonas aeruginosa. Protein Cell. 2015 Jan;6(1):26-41.  [Content Brief]

    [4]. Zhang M, et al. Equisetin as potential quorum sensing inhibitor of Pseudomonas aeruginosa. Biotechnol Lett. 2018 May;40(5):865-870.  [Content Brief]

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