Deoxylimonin

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Deoxylimonin  纯度: 99.49%

Desoxylimonin 是一种具有口服活性的三萜类化合物，可从葡萄柚种子中发现。Desoxylimonin 对乳腺癌细胞有抗增殖活性，其衍生物显示出更好的抗癌、镇痛和抗炎活性。

Deoxylimonin

Deoxylimonin Chemical Structure

CAS No. : 989-23-1

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1 mg ￥900 In-stock
5 mg ￥2200 In-stock
10 mg ￥3200 In-stock
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Deoxylimonin 相关产品

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生物活性

Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound[1].

体外研究
(In Vitro)

Deoxylimonin (0-90 μg/mL, 48 h) treatment shows anti-proliferation activities to breast cancer cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Deoxylimonin 相关抗体:

Cell Proliferation Assay[2]

Cell Line: MDA-MB-435 and MCF-7 cells
Concentration: 0-90 μg/mL
Incubation Time: 48 hours
Result: Showed IC50 values of 0.78 μg/mL and 2.50 μg/mL for MDA-MB-435 and MCF-7 cells, respectively.

体内研究
(In Vivo)

Deoxylimonin (oral administration; 70 mg/kg; once) treatment shows antinociception effects in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice injected with acetic acid[1]
Dosage: 70 mg/kg
Administration: Oral administration; 70 mg/kg; once
Result: Showed the antinociception efficacy (writhing inhibition rate: 24.61%).

分子量

454.51

Formula

C26H30O7
CAS 号

989-23-1
性状

固体

颜色

White to off-white

结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 芸香科
  • 葡萄柚
  • 微生物

Acinetobacter species
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (220.02 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2002 mL 11.0009 mL 22.0017 mL
5 mM 0.4400 mL 2.2002 mL 4.4003 mL
10 mM 0.2200 mL 1.1001 mL 2.2002 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

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动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.49%

Data Sheet (611 KB) SDS (251 KB)

COA (281 KB) HNMR (132 KB) RP-HPLC (317 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Shaochi Wang, et al. Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs. Bioorg Chem. 2020 Jul;100:103886.  [Content Brief]

    [2]. N. Guthri, et al. Inhibition of Human Breast Cancer Cells by Citrus Limonoids. ACS Symposium SeriesVol. 758, July 30, 2000.

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