Cimicifugoside

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Cimicifugoside 

Cimicifugoside 是一种从升麻单胞菌 Cimicifuga simplex 中提取的三萜类化合物，是一种新型特异性核苷转运 (nucleoside transport) 抑制剂，协同增强甲氨蝶呤细胞毒性作用。Cimicifugoside 具有免疫抑制活性，其优先针对 B 细胞功能，需要较大剂量来抑制 T 细胞功能。

Cimicifugoside

Cimicifugoside Chemical Structure

CAS No. : 66176-93-0

规格 价格 是否有货 数量
1 mg ￥2082 1 周
5 mg 询价
10 mg 询价
25 mg 询价

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Cimicifugoside 相关产品

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生物活性

Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2].

IC50 & Target

Nucleoside transport[1]
分子量

674.82

Formula

C37H54O11
CAS 号

66176-93-0
结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 毛茛科
  • 升麻
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (531 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Yawata A, et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. Eur J Pharm Sci. 2009 Nov 5;38(4):355-61.  [Content Brief]

    [2]. Hemmi H, et al. The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. J Pharmacobiodyn. 1980 Dec;3(12):643-8.  [Content Brief]

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