Clemastanin B (Synonyms: 直铁线莲宁B)

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Clemastanin B  (Synonyms: 直铁线莲宁B) 纯度: 99.71%

Clemastanin B 是一种木质素，通过抑制病毒增殖、预防和阻断病毒附着而具有强大的抗流感 (anti-influenza) 活性。Clemastanin B 靶向病毒内吞作用、脱壳或核糖核蛋白 (RNP) 从细胞核输出。Clemastanin B 具有抗氧化和抗炎活性。

Clemastanin B (Synonyms: 直铁线莲宁B)

Clemastanin B Chemical Structure

CAS No. : 112747-98-5

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5 mg ￥3870 In-stock
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生物活性

Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities[1][2][3].

体外研究
(In Vitro)

Clemastanin B inhibits different subtypes of human (H1N1, including swine-origin H1N1; H3N2 and influenza B) and avian influenza viruses (H6N2, H7N3, H9N2) at different magnitudes of activity (IC50 0.087-0.72 mg/ml) while this compound was inactive against respiratory syncytial virus (RSV), adenovirus 3 (ADV3), parainfluenza virus 3 (PIV3), enterovirus 71 (EV71) and human rhinovirus (HRV)[1].
Clemastanin B (0.05, 0.1, 0.2, 0.4 mg/ml; for 8 hours) treatment results in nucleoprotein (NP) distribution in the nuclei in MDCK cells[1].
Clemastanin B (48-72 h) after virus incubation (MOI, 0.01; for 2 h) causes a pronounced titer reduction of progeny virus in MDCK cells[1].
Clemastanin B (pre-incubated for 2 h) has no protective effect on MDCK cell lines with influenza virus[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clemastanin B 相关抗体:
分子量

684.68

Formula

C32H44O16
CAS 号

112747-98-5
性状

固体

颜色

White to off-white

中文名称

直铁线莲宁B
结构分类
  • Phenylpropanoids
  • Lignans
初始来源
  • 植物
  • 十字花
  • 板蓝根
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.71%

Data Sheet (532 KB) SDS (0 KB)

COA (196 KB) HNMR (143 KB) RP-HPLC (383 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Zifeng Yang, et al. Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro. Int J Mol Med. 2013 Apr;31(4):867-73.  [Content Brief]

    [2]. Ping Xiao, et al. Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis). J Tradit Chin Med. 2016 Jun;36(3):369-76.  [Content Brief]

    [3]. Ping Xiao, et al. In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion. J Ethnopharmacol. 2014 Nov 18;157:55-61.  [Content Brief]

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