Quinine hemisulfate hydrate (Synonyms: 硫酸奎宁水合物)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Quinine hemisulfate hydrate (Synonyms: 硫酸奎宁水合物)

Quinine hemisulfate hydrate 是一种从金鸡纳树皮中提取的生物碱，具有抗疟疾的作用。Quinine hemisulfate hydrate 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (K_Ca5.1) 通道 +100 mV 电流, 其 IC₅₀ 值为 169 μM。

Quinine hemisulfate hydrate Chemical Structure

CAS No. : 207671-44-1

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生物活性

Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV, with an IC₅₀ of 169 μM^[1]^[2].

IC₅₀ & Target

IC50: Parasite^[1], 169 μM (mSlo3)^[2]

Clinical Trial

分子量

391.48

Formula

C₂₀H₂₄N₂O₂.1/2H₂O₄S.H₂O

CAS 号

207671-44-1

中文名称

硫酸奎宁水合物

结构分类

Alkaloids
Quinoline Alkaloids

初始来源

植物
茜草科
金鸡纳树

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (538 KB) 产品使用指南 (1538 KB)

参考文献

[1]. Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144. [Content Brief]

[2]. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63. [Content Brief]

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