S-Adenosyl-L-methionine (Synonyms: S-腺苷-L-蛋氨酸; S-Adenosyl methionine; Ademetionine; AdoMet)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
S-Adenosyl-L-methionine (Synonyms: S-腺苷-L-蛋氨酸; S-Adenosyl methionine; Ademetionine; AdoMet)

S-Adenosyl-L-methionine (S-Adenosyl methionine) 是一种具有口服活性的甲基供体。S-Adenosyl-L-methionine 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂。S-Adenosyl-L-methionine 在癌症中还具有抗增殖、促凋亡和抗转移作用。S-Adenosyl-L-methionine 可用于肝病和骨关节炎的研究。

S-Adenosyl-L-methionine (Synonyms: S-腺苷-L-蛋氨酸; S-Adenosyl methionine; Ademetionine; AdoMet)

S-Adenosyl-L-methionine Chemical Structure

CAS No. : 29908-03-0

规格		是否有货
50 mg		询价
100 mg		询价
250 mg		询价

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S-Adenosyl-L-methionine 的其他形式现货产品:

S-Adenosyl-L-methionine tosylate S-Adenosyl-L-methionine-d₃ S-Adenosyl-L-methionine disulfate tosylate

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生物活性

S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research^[1]^[2]^[3].

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

S-Adenosyl-L-methionine (300 µM, 24 或 48 h) 诱导细胞凋亡，并促进 Cal-33 和 JHU-SCC-011 细胞的细胞周期停滞^[4]。
S-Adenosyl-L-methionine (300 µM, 24 h) 减少 Cal-33 和 JHU-SCC-011 细胞的迁移^[4]。
S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 通过调节 DNMTs 的表达保护 5‑FU 的抗癌作用^[5]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

S-Adenosyl-L-methionine 相关抗体:

Apoptosis Analysis^[4]

Cell Line:	Cal-33 and JHU-SCC-011 cells
Concentration:	300 µM
Incubation Time:	24 h (Cal-33) or 48 h (HU-SCC-011)
Result:	Showed an approximately 10% and 3%of apoptotic cells respectively.

Cell Cycle Analysis^[4]

Cell Line:	Cal-33 and JHU-SCC-011 cells
Concentration:	300 µM
Incubation Time:	24 h (Cal-33) or 48 h (HU-SCC-011)
Result:	Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

体内研究
(In Vivo)

S-Adenosyl-L-methionine (30 mg/kg，口服，持续 3 天) 可预防幼鼠出生后早期丙戊酸暴露引起的 ASD 样行为^[6]。
S-Adenosyl-L-methionine (50 和 100 mg/kg，口服) 在戊四唑诱导的大鼠癫痫模型中表现出抗癫痫、记忆增强和抗氧化特性^[7]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Valproic acid treated young mice^[6]
Dosage:	30 mg/kg
Administration:	p.o., for 3 days
Result:	Alleviated most ASD like neurobehavioral symptoms. Normalized the redox potential in the prefrontal cortex.

Clinical Trial

分子量

398.44

Formula

C₁₅H₂₂N₆O₅S

CAS 号

29908-03-0

性状

固体

颜色

Off-white to light yellow

中文名称

S-腺苷-L-蛋氨酸

结构分类

Others

初始来源

内源性代谢物
人肠道微生物代谢物

微生物

Escherichia coli

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO 中的溶解度 : 100 mg/mL (250.98 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H₂O 中的溶解度 : ≥ 43 mg/mL (107.92 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5098 mL	12.5489 mL	25.0979 mL
5 mM	0.5020 mL	2.5098 mL	5.0196 mL
10 mM	0.2510 mL	1.2549 mL	2.5098 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

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纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (613 KB) SDS (393 KB)

COA (266 KB)

产品使用指南 (1538 KB)

参考文献

[1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. [Content Brief]

[2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [Content Brief]

[3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42. [Content Brief]

[4]. Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. [Content Brief]

[5]. Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. [Content Brief]

[6]. Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. [Content Brief]

[7]. Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157. [Content Brief]

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S-Adenosyl-L-methionine 相关产品

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S-Adenosyl-L-methionine 相关抗体:

摩尔计算器

稀释计算器