Methyldopa hydrochloride (Synonyms: 盐酸甲基多巴; L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride)

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Methyldopa hydrochloride  (Synonyms: 盐酸甲基多巴; L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride)

Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) 是一种 α-肾上腺素能激动剂（对 α2-adrenergic receptors 有选择性）。Methyldopa hydrochloride 是一种前体，在中枢神经系统中被代谢 (α-Methylepinephrine)。

Methyldopa hydrochloride (Synonyms: 盐酸甲基多巴; L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride)

Methyldopa hydrochloride Chemical Structure

CAS No. : 884-39-9

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Methyldopa hydrochloride 的其他形式现货产品:

Methyldopa hydrate

Methyldopa hydrochloride 相关产品

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生物活性

Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

IC50 & Target

α adrenergic receptor

 

体内研究
(In Vivo)

Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 60-day-old male rats[2]
Dosage: 200 mg/kg
Administration: I.p.
Result: Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.

Clinical Trial

分子量

247.68

Formula

C10H14ClNO4
CAS 号

884-39-9
中文名称

盐酸甲基多巴； 盐酸卡比多巴EP杂质A
结构分类
  • Alkaloids
  • Other Alkaloids
  • Phenols
  • Polyphenols
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (531 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.  [Content Brief]

    [2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.  [Content Brief]

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