Triacetonamine monohydrate (Synonyms: 四甲基哌啶酮一水合物; 2,2,6,6-Tetramethyl-4-piperidone monohydrate)

发表于由

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Triacetonamine monohydrate  (Synonyms: 四甲基哌啶酮一水合物; 2,2,6,6-Tetramethyl-4-piperidone monohydrate)

Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate 用作合成医药产品、农药和聚合物光稳定剂的中间体。Triacetonamine hydrochloride 具有口服活性，可诱导大鼠急性肝衰竭 (ALF)。

Triacetonamine monohydrate (Synonyms: 四甲基哌啶酮一水合物; 2,2,6,6-Tetramethyl-4-piperidone monohydrate)

Triacetonamine monohydrate Chemical Structure

CAS No. : 10581-38-1

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine hydrochloride has oral activity and can induce acute liver failure (ALF) in rats[1][2].

体内研究
(In Vivo)

Triacetonamine (购自 Shanghai Jinpan Biotech Co Ltd；200 mg、300 mg、400 mg/Kg/天；灌胃；2 天) monohydrate 显示在剂量为 300 mg/Kg/天和 400 mg/Kg/天会出现典型的 ALF 肝肠病理学，而 400 mg/Kg/day组的死亡率较高[2]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (half male and female, 6-8 weeks old, 200 ± 10 g)[2]
Dosage: 200 mg, 300 mg, 400 mg/Kg
Administration: Gavage; daily; 2 days
Result: Showed typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality.

分子量

173.25

Formula

C9H19NO2
CAS 号

10581-38-1
中文名称

四甲基哌啶酮一水合物
结构分类
  • Alkaloids
  • Piperidine Alkaloids
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Cao JP, et al. Triacetonamine formation in a bio-oil from fast pyrolysis of sewage sludge using acetone as the absorption solvent. Bioresour Technol. 2010;101(11):4242-4245.  [Content Brief]

    [2]. Cao JP, et al. Triacetonamine formation in a bio-oil from fast pyrolysis of sewage sludge using acetone as the absorption solvent. Bioresour Technol. 2010 Jun;101(11):4242-5.  [Content Brief]

    [3]. Ting Jiang, et al. Application of Bone Marrow Mesenchymal Stem Cells Effectively Eliminates Endotoxemia to Protect Rat from Acute Liver Failure Induced by Thioacetamide. Tissue Eng Regen Med. 2022 Apr;19(2):403-415.  [Content Brief]

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