Oenothein B (Synonyms: 月见草素B)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Oenothein B  (Synonyms: 月见草素B) 纯度: 95.11%

Oenothein B 是一种二聚体大环鞣花单宁，具有广泛的药理活性，包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。

Oenothein B (Synonyms: 月见草素B)

Oenothein B Chemical Structure

CAS No. : 104987-36-2

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1 mg ￥1100 In-stock
5 mg ￥3500 In-stock
10 mg ￥5200 In-stock
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生物活性

Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].

体外研究
(In Vitro)

Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1].
Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1].
Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1].
A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Oenothein B 相关抗体:

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours
Result: Effectively inhibited the proliferation of A549 cells.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: Induced apoptosis in A549 cells.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: Arrested cells in the G1 phase.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.

体内研究
(In Vivo)

Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1569.08

Formula

C68H48O44
CAS 号

104987-36-2
性状

固体

颜色

White to light yellow

中文名称

月见草素B
结构分类
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (79.66 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6373 mL 3.1866 mL 6.3732 mL
5 mM 0.1275 mL 0.6373 mL 1.2746 mL
10 mM 0.0637 mL 0.3187 mL 0.6373 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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纯度 & 产品资料

纯度: 95.11%

Data Sheet (617 KB) SDS (251 KB)

COA (215 KB) HNMR (437 KB) RP-HPLC (207 KB) MS (71 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120.  [Content Brief]

    [2]. Satoru Tamura, et al. Oenothein B, dimeric hydrolysable tannin inhibiting HCV invasion from Oenothera erythrosepala. J Nat Med. 2019 Jan;73(1):67-75.  [Content Brief]

    [3]. Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14(5):9767-78.  [Content Brief]

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