S-Adenosyl-L-methionine (1,4-butanedisulfonate) (Synonyms: S-Adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate))

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
S-Adenosyl-L-methionine (1,4-butanedisulfonate)  (Synonyms: S-Adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate))

S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate 是一种具有口服活性的甲基供体。S-Adenosyl-L-methionine 1,4-butanedisulfonate 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂。S-Adenosyl-L-methionine 1,4-butanedisulfonate 在癌症中还具有抗增殖、促凋亡和抗转移作用。S-Adenosyl-L-methionine 1,4-butanedisulfonate 可用于肝病和骨关节炎的研究。

S-Adenosyl-L-methionine (1,4-butanedisulfonate) (Synonyms: S-Adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate))

S-Adenosyl-L-methionine (1,4-butanedisulfonate) Chemical Structure

CAS No. : 200393-05-1

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

S-Adenosyl-L-methionine (1,4-butanedisulfonate) 的其他形式现货产品:

S-Adenosyl-L-methionine tosylate S-Adenosyl-L-methionine-d3

S-Adenosyl-L-methionine (1,4-butanedisulfonate) 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

体外研究
(In Vitro)

S-Adenosyl-L-methionine (300 µM, 24 或 48 h) 1,4-butanedisulfonate 诱导细胞凋亡，并促进 Cal-33 和 JHU-SCC-011 细胞的细胞周期停滞[4]。 S-Adenosyl-L-methionine (300 µM, 24 h) 1,4-butanedisulfonate 减少 Cal-33 和 JHU-SCC-011 细胞的迁移[4]。 S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 1,4-butanedisulfonate 通过调节 DNMTs 的表达保护 5‑FU 的抗癌作用[5]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

S-Adenosyl-L-methionine (1,4-butanedisulfonate) 相关抗体:

Apoptosis Analysis[4]

Cell Line: Cal-33 and JHU-SCC-011 cells
Concentration: 300 µM
Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

Cell Cycle Analysis[4]

Cell Line: Cal-33 and JHU-SCC-011 cells
Concentration: 300 µM
Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

体内研究
(In Vivo)

S-Adenosyl-L-methionine (30 mg/kg，口服，持续 3 天) 1,4-butanedisulfonate 可预防幼鼠出生后早期丙戊酸暴露引起的 ASD 样行为[6]。 S-Adenosyl-L-methionine (50 和 100 mg/kg，口服) 1,4-butanedisulfonate 在戊四唑诱导的大鼠癫痫模型中表现出抗癫痫、记忆增强和抗氧化特性[7]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Valproic acid treated young mice[6]
Dosage: 30 mg/kg
Administration: p.o., for 3 days
Result: Alleviated most ASD like neurobehavioral symptoms.
Normalized the redox potential in the prefrontal cortex.

分子量

616.69

Formula

C19H32N6O11S3
CAS 号

200393-05-1
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (545 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.  [Content Brief]

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.  [Content Brief]

    [3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.  [Content Brief]

    [4]. Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224.  [Content Brief]

    [5]. Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378.  [Content Brief]

    [6]. Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74.  [Content Brief]

    [7]. Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务