L-Epinephrine sulfate (Synonyms: (-)-Epinephrine sulfate; L-Adrenaline sulfate; (-)-Adrenalin sulfate)

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L-Epinephrine sulfate  (Synonyms: (-)-Epinephrine sulfate; L-Adrenaline sulfate; (-)-Adrenalin sulfate)

L-Epinephrine ((-)-Epinephrine, L-Adrenaline) sulfate 是一种由肾上腺髓质分泌的口服活性激素。L-Epinephrine sulfate 是一种 α-adrenergic 和 β-adrenergic 受体激动剂。L-Epinephrine sulfate 可用于研究过敏反应。L-Epinephrine sulfate 具有心脏骤停研究潜力[4]。

L-Epinephrine sulfate (Synonyms: (-)-Epinephrine sulfate; L-Adrenaline sulfate; (-)-Adrenalin sulfate)

L-Epinephrine sulfate Chemical Structure

CAS No. : 52455-32-0

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L-Epinephrine sulfate 的其他形式现货产品:

L-Epinephrine

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生物活性

L-Epinephrine ((-)-Epinephrine, L-Adrenaline) sulfate is a orally active hormone secreted by the medulla of the adrenal glands. L-Epinephrine sulfate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine sulfate can be used in the research of anaphylaxis. L-Epinephrine sulfate has the potential for the research of cardiac arrest[1][2][3][4].

IC50 & Target

β adrenergic receptor

 

体内研究
(In Vivo)

L-Epinephrine sulfate (0.75, 1.5, 3 mg/kg; i.p.) exerts oxidative and nitrative stress in rats, increased damage to lipids and proteins, and damage of cardiomyocytes and cytogenetic damage in rats[2].
L-Epinephrine sulfate (0.02, 0.03 mg/kg) increases ABP’s and to some extent also CePP, but significantly decreases organ and brain perfusion in adult pigs[3].
L-Epinephrine sulfate (0.1 mg/kg; s.c.) enhances memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory[6].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 220-280 g, 18 weeks Wistar rats[2]
Dosage: 0.75, 1.5, 3 mg/kg
Administration: IP
Result: Induced a significant rise in CAT activity, MDA level, PCC, NO2−, and 3-NT and a significant decrease in SOD activity, and exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes.
Animal Model: 24-25 month male Fischer-344 rats[6]
Dosage: 0.1 mg/kg
Administration: S.c.
Result: Enhanced memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory.

Formula

C9H13NO3.xH2O4S
CAS 号

52455-32-0
结构分类
  • Alkaloids
  • Other Alkaloids
  • Phenols
  • Polyphenols
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (539 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. McLean-Tooke AP, et al. Adrenaline in the treatment of anaphylaxis: what is the evidence? BMJ. 2003 Dec 6;327(7427):1332-5.  [Content Brief]

    [2]. Radaković M, et al. Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline. Oxid Med Cell Longev. 2018 Nov 21;2018:1805354.  [Content Brief]

    [3]. Hardig BM, et al. Physiologic effect of repeated adrenaline (epinephrine) doses during cardiopulmonary resuscitation in the cath lab setting: A randomised porcine study. Resuscitation. 2016 Apr;101:77-83.  [Content Brief]

    [4]. Callaway CW. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42.  [Content Brief]

    [5]. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44.  [Content Brief]

    [6]. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27.  [Content Brief]

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