Meclofenamic acid sodium hydrate (Synonyms: Meclofenamate sodium hydrate)

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Meclofenamic acid sodium hydrate  (Synonyms: Meclofenamate sodium hydrate)

Meclofenamic acid (Meclofenamate) sodium hydrate 是一种非甾体抗炎剂。Meclofenamic acid sodium hydrate 是一种高选择性的脂肪和肥胖相关酶 (FTO) 抑制剂。Meclofenamic acid sodium hydrate 与 FTO 竞争，与含有 m(6)A 的核酸结合。Meclofenamic acid sodium hydrate 是一种非选择性的缝隙连接 (gap-junction) 阻滞剂。Meclofenamic acid sodium hydrate 抑制 hKv2.1 和 hKv1.1，其 IC50 分别为 56.0 和 155.9 μM。

Meclofenamic acid sodium hydrate (Synonyms: Meclofenamate sodium hydrate)

Meclofenamic acid sodium hydrate Chemical Structure

CAS No. : 67254-91-5

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Meclofenamic acid sodium hydrate 的其他形式现货产品:

Meclofenamic acid

Meclofenamic acid sodium hydrate 相关产品

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生物活性

Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4].

IC50 & Target

IC50: 1 μM (cyclooxygenase), 56.0 μM (hKv2.1), 155.9 μM (hKv1.1)[3]
体外研究
(In Vitro)

Meclofenamic acid sodium hydrate (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner[1].
Meclofenamic acid sodium hydrate inhibits enzyme cyclooxygenase, with an IC50 about 1 μM, thereby inhibiting the production of prostaglandins[2].
Meclofenamic acid sodium hydrate inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Meclofenamic acid sodium hydrate 相关抗体:

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 12.5, 25, 50, 100 μM
Incubation Time: 24 h
Result: Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.

Clinical Trial

分子量

336.15

Formula

C14H12Cl2NNaO3
CAS 号

67254-91-5
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (539 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.  [Content Brief]

    [2]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.  [Content Brief]

    [3]. Lee YT, et al. Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid. Eur J Pharmacol. 1999 Aug 13;378(3):349-56.  [Content Brief]

    [4]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.  [Content Brief]

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