Se-Methylselenocysteine hydrochloride (Synonyms: L-硒甲基硒代半胱氨酸; Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Se-Methylselenocysteine hydrochloride  (Synonyms: L-硒甲基硒代半胱氨酸; Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride)

Se-Methylselenocysteine hydrochloride，甲基硒的前体，具有强大的癌症化学预防活性和抗氧化活性。Se-Methylselenocysteine hydrochloride 具有口服生物活性，可诱导细胞凋亡 (apoptosis)。

Se-Methylselenocysteine hydrochloride (Synonyms: L-硒甲基硒代半胱氨酸; Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride)

Se-Methylselenocysteine hydrochloride Chemical Structure

CAS No. : 863394-07-4

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Se-Methylselenocysteine hydrochloride 的其他形式现货产品:

Se-Methylselenocysteine

Se-Methylselenocysteine hydrochloride 相关产品

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生物活性

Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis[1][2].

体外研究
(In Vitro)

Se-Methylselenocysteine hydrochloride (100-400 μM；3 天) 诱导 SKOV-33 细胞凋亡[1]。
Se-Methylselenocysteine hydrochloride (100-400 μM；3 天) 诱导 caspase-3 介导的细胞凋亡[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Se-Methylselenocysteine hydrochloride 相关抗体:
体内研究
(In Vivo)

Se-Methylselenocysteine hydrochloride (0.2 mg/只小鼠；口服；每日一次，持续 14 天) 在携带人 FaDu 和 A253 头颈异种移植物的裸鼠中增强 CDDP 和环磷酰胺的抗肿瘤活性[2]。
阿尔茨海默氏病 (AD) 小鼠在其饮用水中加入硒-甲基硒代半胱氨酸 (每天 0.75 mg/kg体重) 处理 10 个月。Se-Methylselenocysteine hydrochloride 减少氧化应激和神经炎症；Se-Methylselenocysteine hydrochloride 调节多种金属离子的分布和水平；Se-Methylselenocysteine hydrochloride 通过抑制其前体蛋白 APP 和 β-分泌酶 (BACE1) 的表达来减少淀粉样蛋白-β 肽 (Aβ) 的生成，并通过促进蛋白磷酸酶 2A (PP2A) 活性来减弱 tau 过度磷酸化和神经原纤维缠结 (NFT) 的形成，从而保护突触蛋白和神经元活动，最终改善 AD 模型小鼠的空间学习和记忆缺陷[3]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

218.54

Formula

C4H10ClNO2Se
CAS 号

863394-07-4
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (532 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.  [Content Brief]

    [2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.  [Content Brief]

    [3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.  [Content Brief]

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