Mahanimbine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Mahanimbine 

Mahanimbine 是Murraya koenigii中的一种具有口服活性的生物碱。Mahanimbine 抑制高脂饮食 (HFD) 诱导的小鼠代谢并发症的进展。

Mahanimbine

Mahanimbine Chemical Structure

CAS No. : 21104-28-9

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Mahanimbine 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Mahanimbine is an orally active alkaloid from Murraya koenigii. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice[1].

体内研究
(In Vivo)

Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female)[1].
Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress[1].
Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (7-8 weeks old, both sex)[1]
Dosage: HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine);
Administration: Oral suspension; daily for 12 weeks
Result: Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain.

分子量

331.45

Formula

C23H25NO
CAS 号

21104-28-9
结构分类
  • Alkaloids
  • Indole Alkaloids
  • Alkaloids
  • Carbazole Alkaloids
初始来源
  • 植物
  • 芸香科
  • 调料九里香
  • 植物
  • 芸香科
  • 九里香
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (527 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Jagtap S, et al. Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations. Biofactors. 2017 Mar;43(2):220-231.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务