Tubulysin D (Synonyms: 微管蛋白抑制剂 D)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Tubulysin D  (Synonyms: 微管蛋白抑制剂 D)

Tubulysin D 是具有高细胞毒性的抗微管毒素 (anti-microtubule toxins)，作为 ADC 细胞毒素 (ADC Cytotoxin) 合成 ADC。Tubulysin D 能够从粘细菌 Archangium geophyra 和 Angiococcus disciformis 中分离得到。Tubulysin D 在哺乳动物细胞中显示出极其有效的细胞毒活性，包括多药耐药细胞系，IC50 值在较低的纳摩尔范围内。Tubulysin D 可抑制微管蛋白 (Microtubule/Tubulin) 聚合并导致细胞周期停滞和凋亡 (apoptosis)。

Tubulysin D (Synonyms: 微管蛋白抑制剂 D)

Tubulysin D Chemical Structure

CAS No. : 309935-57-7

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Tubulysin D 相关产品

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生物活性

Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].

IC50 & Target

IC50: 1.7 μM (Tubulin)[1]
体外研究
(In Vitro)

Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulysin D 相关抗体:
分子量

828.07

Formula

C43H65N5O9S
CAS 号

309935-57-7
中文名称

微管蛋白抑制剂 D
结构分类
  • Others
初始来源
  • 微生物

Archangium geophyra、Angiococcus disciformis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Shibue T, et al. Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. Bioorg Med Chem Lett. 2011 Jan 1;21(1):431-4.  [Content Brief]

    [2]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.  [Content Brief]

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